For the paper “ Localized Motif Discovery in Gene Regulatory Sequences ”
نویسندگان
چکیده
LocalMotif uses a combination of three different scoring functions which individually describe three different characteristics of a motif. The relative entropy score (RES) measures the degree of surprise in the motif nucleotide pattern with respect to the background distribution of nucleotides. The over-representation score (ORS) measures the overabundance of the number of instances of the motif. The spatial confinement score (SCS) measures the disproportionate confinement of motif instances in a certain sequence interval. All three scores are expressed as entropies and brought to a normalized form. The scoring functions and their normalization is described below.
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تاریخ انتشار 2010